Swimming with the (pep)tides
April 6 @ 10:00 AM - 11:00 AM PDT
Stephen L. Gasior, Ph.D

Yabe, D., Seino, Y., & Seino, Y. (2018). Incretin concept revised: The origin of the insulinotropic function of glucagon‐like peptide‐1–the gut, the islets or both?. Journal of diabetes investigation, 9(1), 21-24.
https://onlinelibrary.wiley.com/doi/full/10.1111/jdi.12718

Pacini, G., & Ahrén, B. (2017). Glucagon‐like peptide‐1 and glucose‐dependent insulinotropic peptide: effects alone and in combination on insulin secretion and glucose disappearance in mice. Physiological reports, 5(11), e13280.
https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.13280

Underwood, C. R., Garibay, P., Knudsen, L. B., Hastrup, S., Peters, G. H., Rudolph, R., & Reedtz-Runge, S. (2010). Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor. Journal of Biological Chemistry, 285(1), 723-730.
https://www.sciencedirect.com/science/article/pii/S0021925820661580

Madsen, O. D., Karlsen, C., Blume, N., Jensen, H. I., Larsson, L. I., & Holst, J. J. (1995). Transplantable glucagonomas derived from pluripotent rat islet tumor tissue cause severe anorexia and adipsia. Scandinavian Journal of Clinical and Laboratory investigation. Supplementum, 220, 27-35.
https://pubmed.ncbi.nlm.nih.gov/7652479/

Knudsen, L. B., & Lau, J. (2019). The discovery and development of liraglutide and semaglutide. Frontiers in endocrinology, 10, 440904.
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00155/full

https://en.wikipedia.org/wiki/Liraglutide

https://en.wikipedia.org/wiki/Semaglutide

https://en.wikipedia.org/wiki/Tirzepatide

Mun, Y., Kim, W., & Shin, D. (2023). Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects. International journal of molecular sciences, 24(15), 12152.
https://www.mdpi.com/1422-0067/24/15/12152

https://www.fda.gov/news-events/press-announcements/fda-approves-first-treatment-increase-pain-free-light-exposure-patients-rare-disorder

https://en.wikipedia.org/wiki/Afamelanotide

https://en.wikipedia.org/wiki/Melanotan_II

https://en.wikipedia.org/wiki/Bremelanotide

King, S. H., Mayorov, A. V., Balse-Srinivasan, P., Hruby, V. J., Vanderah, T. W., & Wessells, H. (2007). Melanocortin receptors, melanotropic peptides and penile erection. Current topics in medicinal chemistry, 7(11), 1111-1119.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694735/

original overdose citation to which I do not have access:
Hadley, M. E. (2005). Discovery that a melanocortin regulates sexual functions in male and female humans. Peptides, 26(10), 1687-1689.
https://www.sciencedirect.com/science/article/abs/pii/S0196978105002305

MC4R gene website
https://www.mc4r.org.uk/

Tao, Y. X. (2010). The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocrine reviews, 31(4), 506-543.
https://academic.oup.com/edrv/article/31/4/506/2195018

Zhang, J., Li, S., Luo, X., & Zhang, C. (2023). Emerging role of hypothalamus in the metabolic regulation in the offspring of maternal obesity. Frontiers in Nutrition, 10, 1094616.
https://www.frontiersin.org/articles/10.3389/fnut.2023.1094616/full