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UID:10504-1633168800-1633172400@www.sciencecircle.org
SUMMARY:What is it about The Science Circle and Second Life?
DESCRIPTION:Second Life and The Science Circle has been going strong for over 13 years. That is a longer time than almost any of today’s social media platforms. \nWhat does Second Life and The Science Circle mean to you? How do they differ from social media? How is communicating or interacting with other people different in a virtual world than in other ways to meet online? How does it differ from being together in person?\nThis will be a relaxed and informal conversation about this topic. We would love to hear from you and your point of view on this fascinating social phenomenon. \n  \nNon-members only need to register once. \nIs this the first time you will attend a presentation with us?\nFollow this link first.
URL:https://www.sciencecircle.org/event/what-is-it-about-sc-and-sl/
LOCATION:Fireside
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DTSTART;TZID=America/Los_Angeles:20211002T210000
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UID:10400-1633208400-1633212000@www.sciencecircle.org
SUMMARY:Mitochondrial Dysfunction and Failure in Human Disease
DESCRIPTION:Mitochondrial Dysfunction and Failure in Human Disease\nSome two billion years ago\, a seminal\, endosymbiotic event occurred: a larger\, anaerobic bacterial cell ingested a smaller\, aerobic prokaryotic ‘germ’. This beneficial union of two life forms led to the evolution of more highly organized eukaryotic cells with mitochondria as subcellular organelles. These mitochondria still retain their own bacteria-like DNA – they also replicate themselves. As the metabolic power source for eukaryotic cells\, mitochondria utilize (detoxify) oxygen to produce energy\, an attribute that has made possible the rise of multi-cellular organisms and higher life forms. Mitochondria are vital to cellular life and therefore\, to human life. Unfortunately\, they can also be subject to genetically-based errors of metabolism. \nThe mammalian mitochondrial genome (circular\, double-stranded DNA) encodes 2 rRNAs\, 22 tRNAs and mRNAs for 13 polypeptides of the oxidative phosphorylation (OxPhos) system -this is the water brigade-like\, mitochondrial-membrane bound\, Electron Transport Chain that drives the proton pump\, which in turn\, drives production of ATP with a high energy phosphate bond to sustain cellular biochemistry (purposeful energy production and utilization required for sustenance of life processes). \nMitochondrial diseases have been recognized in the past 30 years as a group of genetic disorders characterized by defects in oxidative phosphorylation. These are attributable both to mutations in genes that encode structural mitochondrial proteins or proteins involved in mitochondrial function: \n\nthese mutations include genes in nuclear (chromosomal) DNA (nDNA) as well as mitochondrial DNA (mtDNA).\n\nMitochondrial diseases as a group of inherited metabolic disorders are in fact\, among the most common forms of inherited neurological disorders. Diagnosis is often delayed: \n\ndue to non-specific and varied symptom\n\nwhich can range from fatigue and exercise intolerance to failure to thrive in children\, autism\, dementia\, diabetes mellitus;\n\n\nand finally\, lack of suspicion for\, or lack of awareness of mitochondrial diseases on the part of the diagnostician.\n\n \n  \nAdvances in sequencing techniques of mitochondria have substantially improved diagnosis\, particularly in children. In our REVIEW of HUMAN DISEASE of MITOCHONDRIAL ETIOLOGY\, we will discuss common presenting symptoms – in particular\, those involving organs with high energy requirements: central nervous system\, cardiac and skeletal muscle\, renal tubules\, to name a few. Medical management of mitochondrial diseases will be considered along with some attention to “mitochondrial health”. \nPresentation by Robert A. Hendrix\, M.D. \n  \n  \nNon-members only need to register once. \nIs this the first time you will attend a presentation with us?\nFollow this link first.
URL:https://www.sciencecircle.org/event/mitochondrial-dysfunction-and-failure-in-human-disease/
LOCATION:Auditorium
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